If you know that life is basically going to be horrendously difficult at best and all but unlivable at worst or possibly even unlivable do you go on? And the choice to go on is the only thing that I think can be called hope. Because if hope isn't forced to encounter the worst possibility then it's a lie.

The worst enemy of human hope is not brute facts but men of brains who will not face them.

Hope in reality is the worst of all evils because it prolongs the torments of man.

The worst feeling in the world is the homesickness that comes over a man occasionally when he is at home.

The worst mistake of first contact made throughout history by individuals on both sides of every new encounter has been the unfortunate habit of making assumptions. It often proved fatal.

Smoking is the now the principal avoidable cause of premature death in Britain. It hits the worst off people hardest of all. Smoking is one of the principal causes of the health gap which leads to poorer people being ill more often and dying sooner.

There's definitely evidence that capitalism at its most ruthless rewards psychopathic behavior. When you look at the worst corners of the American health insurance industry or the sub-prime banking market it really feels like the more psychopathically someone behaves the more it's rewarded.

Obama seemed poised to realign American politics after his stunning 2008 victory. But the economy remains worse than even the administration's worst-case scenarios and the long legislative battles over health care reform financial services reform and the national debt and deficit have taken their toll. Obama no longer looks invincible.

The worst thing that can happen to a man is to lose his money the next worst his health the next worst his reputation.

We all have to work for happiness. And you cannot listen to other people. That is the worst mistake you can make.