Your 40s are a major trough. About the age of 50 feelings of satisfaction begin to rebound and keep rising into your 50s 60s and 70s with health being a major factor.
The age in which we live this non-stop distraction is making it more impossible for the young generation to ever have the curiosity or discipline... because you need to be alone to find out anything.
Our age knows nothing but reaction and leaps from one extreme to another.
An artist must be a reactionary. He has to stand out against the tenor of the age and not go flopping along.