To me there has never been a higher source of earthly honor or distinction than that connected with advances in science.

Romance should never begin with sentiment. It should begin with science and end with a settlement.

Whenever anyone says 'theoretically ' they really mean 'not really.'

Facts are the air of scientists. Without them you can never fly.

Science never solves a problem without creating ten more.

I had never felt so lonely and so sad in my entire life.

One of the sad commentaries on the way women are viewed in our society is that we have to fit one category. I have never felt that I had to be in one category.

I would never have become music director of the Chicago Symphony which would have been an extremely sad loss.

Nolan has the strangest affect on people. You know I think there's something very sad and little boy about him but at the same time the way he goes about everything is so awkward and obnoxious. He can never say the right thing you know? And I think if he just didn't try so hard and calmed down people might actually like him a bit more!

I never was a great Thatcher fan and it wasn't a sad day in my life when she resigned.