We have to challenge the whole idea that it's acceptable for a society like Britain to have such a significant number of people who do not work one day of the week and don't have any possibility of improving the quality of their lives.

Without intervention today the cost of care for adults with autism will be significantly greater and the burden will no longer lie with the parents but on our entire society.

Although I don't have a prescription for what others should do I know I have been very fortunate and feel a responsibility to give back to society in a very significant way.

When trying to remember my share in the glow of the eternal present in the smile of God I return to my childhood too for that is where the most significant discoveries turn up.

I am one of those scientists who feels that it is no longer enough just to get on and do science. We have to devote a significant proportion of our time and resources to defending it from deliberate attack from organised ignorance.

Saturdays and Sundays America in the year 2009 does not in some ways differ significantly from the country that existed almost 50 years ago. This is truly sad.

Romance is thinking about your significant other when you are supposed to be thinking about something else.

I think we need to significantly reduce the regulatory burden on the private sector. The Obama administration is doing the opposite. They're loading on more and more regulation on the private respect to how the economy functions.

Even the most understated ceremony involves a certain respect for ritual and pageantry. No one plays more of a significant role than the bride's attendants.

The 'anti-globalisation movement' is the most significant proponent of globalisation - but in the interests of people not concentrations of state-private power.