Willem de Kooning is generally credited for coming out of the painterly gates strong in the forties revolutionizing art and abstraction and reaching incredible heights by the early fifties and then tailing off.
Cosmologists have attempted to account for the day-to-day laws you find in textbooks in terms of fundamental 'superlaws ' but the superlaws themselves must still be accepted as brute facts. So maybe the ultimate laws of nature will always be off-limits to science.
