There are movies that require fantasy and slightly more fantastical acting. Lines that are good for certain movies in real life circumstances would be absolutely unbelievable things to really say and you would look at these people like they're freaks for conversing that way. But somehow for certain styles of movies it works and it seems fine.
The comics that are just conversing with you up there and drawing on their own life yeah I guess so. I guess some do political humor some do topical humor but the ones that I like the ones that are appealing to me were guys who were just talking to you about their life.