You've got to honor your relationship with your audience - that they sit down because they want to be entertained. And that doesn't mean you can't provoke them and antagonize them and challenge them in the course of the entertainment as long as you keep the entertainment part of the equation alive.

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The Carter Center has the only existing international taskforce on disease eradication. Which means a total elimination of a disease on the face of the Earth. In the history of the world there's only been one disease eradicated: smallpox. The second disease I think is gonna be guinea worm.