If we bring not the good courage of minds covetous of truth and truth only prepared to hear all things and decide upon all things according to evidence we should do more wisely to sit down contented in ignorance than to bestir ourselves only to reap disappointment.

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One thing that being a scientist has taught me is that you can never be certain about anything. You never know the truth. You can only approach it and hope to get a bit nearer to it each time. You iterate towards the truth. You don't know it.